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Literature summary extracted from

  • Masuda, S.; Fujishima, Y.; Maeda, N.; Tsugawa-Shimizu, Y.; Nakamura, Y.; Tanaka, Y.; Obata, Y.; Fukuda, S.; Nagao, H.; Kita, S.; Nishizawa, H.; Shimomura, I.
    Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity (2019), Am. J. Physiol. Endocrinol. Metab., 316, E239-E250 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.4.50 medicine the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice Rattus norvegicus
3.1.4.50 medicine the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice Homo sapiens
3.1.4.50 medicine the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.50 Homo sapiens P80108
-
-
3.1.4.50 Mus musculus Q7TNZ4
-
-
3.1.4.50 Rattus norvegicus Q8R2H5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.50 hepatocyte primary hepatocyte Rattus norvegicus
-
3.1.4.50 liver highest expression level Mus musculus
-
3.1.4.50 serum
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.50 Gpld1
-
 Rattus norvegicus
3.1.4.50 Gpld1
-
 Homo sapiens
3.1.4.50 Gpld1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.4.50 Rattus norvegicus the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice up
3.1.4.50 Homo sapiens the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice up
3.1.4.50 Mus musculus the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice up

General Information

EC Number General Information Comment Organism
3.1.4.50 physiological function GPI-PLD directly regulates intracellular diacylglycerol content in primary hepatocytes. Serum GPI-PLD levels are strongly and independently associated with serum alanine transaminase and triglyceride levels in male subjects with metabolic syndrome Rattus norvegicus
3.1.4.50 physiological function mice lacking GPI-PLD exhibit glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Diacylglycerol content is significantly decreased, and protein kinase PKCepsilon activity is suppressed in the livers of knockout mice Mus musculus
3.1.4.50 physiological function serum GPI-PLD level is strongly and independently associated with serum alanine transaminase and triglyceride levels in human male subjects Homo sapiens